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What are hyaluronic acid dermal fillers?

Dermal fillers are injection treatments used to diminish wrinkles, restore fullness, or make subtle changes.

Hyaluronic acid (HA) is a naturally occurring substance in your skin that helps provide hydration, fullness, and elasticity.1 It diminishes as we age, causing skin to lose volume while increasing the chances for wrinkles and folds to appear.

Restylane dermal fillers use clear gel formulations of HA. As the original non-animal stabilized HA filler, Restylane was designed to be closest to the body's own hyaluronic acid with minimal crosslinking,2*† and was the first to be approved by the US FDA. The Restylane portfolio has now been used in over 65 million treatments worldwide.3

*Depending on the product used and area treated.
NASHA products (Restylane-L, Restylane Lyft, Restylane Silk, and Restylane Eyelight) have less than 1% crosslinking.
Hyaluronic acid graphic
*Depending on the product used and area treated.
NASHA products (Restylane-L, Restylane Lyft, Restylane Silk, and Restylane Eyelight) have less than 1% crosslinking.

Our innovative hyaluronic acid (HA) gel technologies

The Restylane range of products are created with two patented technologies, NASHA® and XpresHAn TechnologyTM.

kysse_sweettoothed
 
  • Products formulated with XpresHAn TechnologyTM include Restylane Contour, Restylane Kysse, Restylane Defyne and Restylane Refyne.
XpresHAn TechnologyTM is designed for movement and expression.1 It has a soft gel texture with high flexibility and integrates into the tissue.5,6
  • Provides flexible support to follow face’s natural expression.4,7
  • Intended for dynamic areas of the face.4,7
  • More than 20 sponsored clinical studies completed or in progress worldwide.8
kysse_sweettoothed
 
  • Products formulated with NASHA Technology include Restylane-L, Restylane Lyft, Restylane Silk, and Restylane Eyelight.
NASHA® Technology is engineered for precision and structure.9 It has a firm gel texture intended for a more pronounced lift.6
  • Provides support for targeted projection and precision6,9
  • Closest to the body’s own hyaluronic acid2
  • More than 30 sponsored clinical trials completed or in progress8

HA gel placement

Restylane® Hyaluronic acid gel placement

Many of my patients seek treatment for hollows under the eyes, and topical products such as creams, concealers, and undereye masks just aren’t able to solve the problem and provide the long-lasting results they are seeking.

I’m pleased to see that Restylane Eyelight offers a safe, effective, and natural-looking outcome that enables my patients to achieve their aesthetic undereye goals, with results that last up to 18 months with optimal treatment.” 10,11

Carolyn Jacob, MD
Board Certified Dermatologist and Medical Director
Chicago Cosmetic Surgery and Dermatology
Galderma Clinical Study investigator supporting Restylane treatment
Galderma Clinical Study Investigator
You can imagine that I have used many fillers throughout my career. However, I’ve found that Restylane products, especially the ones with XpresHAn TechnologyTM, provide such a natural look that’s undoubtedly them.”
Cheri Frey, MD, FAAD
Howard University Hospital
Howard Faculty Practice Plan
Washington, DC
kysse_sweettoothed
Galderma Clinical Study Investigator

Frequently Asked Questions

Dermal fillers are injectable treatments that can help to diminish the appearance of wrinkles while restoring volume and fullness in the face and hands, or to re-shape features to meet aesthetic goals, such as achieving a fuller lip or correcting the appearance of a recessed chin.1,2

There are several types of dermal fillers, one being hyaluronic acid (HA). All Restylane fillers use HA gel technology made of transparent hyaluronic acids, which are sugars naturally found in the skin that help provide hydration, fullness, and elasticity.

References:
  • Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-2202.
  • Data on file. Galderma Laboratories, L.P.

Hyaluronic acid (HA) is a naturally occurring substance in your skin that helps provide hydration, fullness, and elasticity. It diminishes as we age, causing skin to lose volume while increasing the chances for wrinkles and folds to appear.1

Restylane dermal fillers use a clear gel formulation of HA. Restylane was the first non-animal stabilized HA dermal filler to be approved by the US FDA, and has been used in over 65 million treatments worldwide.2

References:
  • Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-220.
  • Data on file. MA-39680 Global 65 Million Restylane Treatments. 2023.

As we age, our skin changes, becoming thinner, losing fat, and no longer looking as plump or smooth as it once did. Facial aging begins in your 20s, when skin firmness starts decreasing as a result of both internal factors (i.e., genetics and natural aging) and external factors (e.g., sun exposure, smoking, stress).1

Hyaluronic acid (HA), collagen, and elastin diminish as we age, causing skin to lose volume and increasing the chances for wrinkles and folds to appear.1 Restylane dermal fillers use a clear gel formulation of HA.

References:
  • Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-22.

Explore other Galderma Aesthetics treatments

There’s more to love from the Galderma Aesthetics portfolio—and more opportunities to get rewarded with ASPIRE.
References
  1. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):253-8.
  2. Kablik J, Monheit GD, Yu L, Chang G. and Gershkovich, J. Comparative Physical Properties of Hyaluronic Acid Dermal Fillers: Dermatologic Surgery 35, 302–312 (2009).
  3. Data on file. MA-39680. Global 55 Million Restylane Treatments, 2022.
  4. Philipp-Dormston WG, Schuster B, Podda M. Perceived naturalness of facial expression after hyaluronic acid filler injection in nasolabial folds and lower face. J Cosmet Dermatol. 2020;19:1600-1606.
  5. Data on file. MA-34483 Study Report. Galderma Laboratories, L.P., 2021.
  6. Lundgren B, Sandkvist U, Bordier N. and Gauthier B. Using a New Photo Scale to Compare Product Integration of Different Hyaluronan-Based Fillers After Injection in Human Ex Vivo Skin. J Drugs Dermatol 2017, 982–986 (2018).
  7. Solish N, et al. Dynamics of hyaluronic acid fillers formulated to maintain natural facial expression. J Cosmet Dermatol. 2018, 738–746 (2019).
  8. Data on file. Galderma Laboratories, L.P.
  9. Nikolis A, Enright KM, Lazarova D, et al. The Role of Clinical Examination in Midface Volume Correction Using Hyaluronic Acid Fillers: Should Patients Be Stratified by Skin Thickness? Aesthet Surg J Open Forum. 2020 Feb 6;2(1):ojaa005
  10. Restylane Eyelight. Instructions for Use. Galderma Laboratories, L.P., 2023.
  11. Data on file. 43USTT1904 Clinical Study Report. Galderma Laboratories, L.P., 2022.
Important Safety Information

The Restylane family of products are indicated for patients over the age of 21, and includes Restylane®, Restylane-L®, Restylane® Lyft with Lidocaine, Restylane® Silk, Restylane® Kysse, Restylane® Refyne, Restylane® Defyne, Restylane® Contour, and Restylane® Eyelight.

Approved Uses

Restylane® and Restylane-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Restylane® and Restylane-L® are also indicated for injection into the lips.

Restylane® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies. Restylane® Lyft with Lidocaine is also indicated for injection into the dorsal hand to correct volume loss.

Restylane® Silk is for lip augmentation and for correction of perioral wrinkles.

Restylane® Kysse is for lip augmentation and for correction of upper perioral wrinkles.

Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.

Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds. Restylane® Defyne is also indicated for injection into the mid-to deep dermis (subcutaneous and/or supraperiosteal) for augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion.

Restylane® Contour is for cheek augmentation and for the correction of midface contour deficiencies.

Restylane® Eyelight is for the improvement of infraorbital hollowing.

Do not use if you have severe allergies with a history of severe reactions (anaphylaxis), are allergic to lidocaine or gram-positive bacterial proteins used to make hyaluronic acid, prone to bleeding, or have a bleeding disorder. The safety of use while pregnant or breastfeeding has not been studied. Tell your doctor if you have a history of scarring or pigmentation disorders as these side effects can occur with hyaluronic acid fillers. Tell your doctor if you are planning other cosmetic treatments (i.e., lasers and chemical peels) as there is a possible risk of inflammation at the injection site.

Tell your doctor if you’re taking medications that lower your body’s immune response or affect bleeding, such as aspirin or warfarin, as these medications may increase the risk of bruising or bleeding at the gel injection site. Using these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete.

The most common side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site, and impaired hand function. Delayed-onset inflammation near the site of dermal filler injections is one of the known adverse events associated with dermal fillers, and cases have been reported to occur at the dermal filler treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site. The risk of unintentional injection into a blood vessel is small but can occur and could result in serious complications, which may be permanent including, vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. As with all skin injection procedures, there is a risk of infection.

To report a side effect with any Restylane® product, please call Galderma Laboratories, L.P at 1-855-425-8722.

To learn more about serious but rare side effects and full Important Safety Information, visit www.RestylaneUSA.com.

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