The Restylane family of products is a brand of hyaluronic acid dermal fillers, which includes Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne and Restylane Defyne. Each is a clear gel formulation of hyaluronic acid specifically formulated to act like your body's own naturally produced hyaluronic acid. Each Restylane product is designed for a specific purpose.1
Restylane Silk is the first FDA-approved product specifically designed for subtle lip augmentation and the smoothing of wrinkles around the mouth. It is composed of a gel that is smaller and smoother than other Restylane products, resulting in a softer, more precise result — ideal for restoring and enhancing the lips. Additionally, Silk is administered via ultrafine needle, which is designed for improved accuracy and precision.
Restylane Lyft is approved for cheek augmentation and the correction of age-related midface contour deficiencies, as well as the treatment of moderate to severe facial folds, such as the nasolabial folds (smile lines). Lyft is the first and only FDA-approved filler with the ability to provide fullness to the cheeks, as well as restore lost volume in the midface area. Lyft contains 0.3% lidocaine, which is added to reduce the discomfort during treatment.
Restylane is used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane is also indicated for lip augmentation.
Restylane Refyne integrates with your skin to help smooth out the lines that run alongside the corners of your mouth (nasolabial folds and marionette lines)7* and the flexibility you need for natural-looking movement and expressions.1,2
Restylane Defyne is designed to act like your body’s own hyaluronic acid to help smooth out deeper lines around your mouth (nasolabial folds and marionette lines)7* while letting you look more natural through a range of facial expressions.1,3,8
Restylane products are approved only for patients over the age of 21.
*XpresHAn Technology™ is known as Optimal Balance Technology outside the US. Restylane Refyne is known as Emervel® Classic and Restylane Defyne is known as Emervel® Deep outside the US.
Dermal fillers are facial injection treatments used to help diminish wrinkles while restoring volume and fullness in the face. There are several types of dermal fillers, one being hyaluronic acid. All Restylane products are transparent hyaluronic acids, which are sugars naturally found in the skin that help provide hydration, fullness and elasticity.
Wrinkles are part of life — our skin changes as we age. It becomes thinner, loses fat, and no longer looks as plump and smooth as it once did. Facial aging actually begins in your 20s, when skin firmness begins to decrease as a result of both internal (genetics and natural aging) and external (sun exposure, smoking, pollution, sleeping positions, etc.) factors.
WHAT HAPPENS AS WE AGE?
The “cupid’s bow” is the double curve of the upper lip, resembling the bow of Cupid, Roman god of love. The upper lip is believed to be most attractive when it is well-defined and when the two sides look the same. Everyone’s facial structure is different, and so is everyone's ideal lip shape and size. Restylane Silk is designed to provide precise lip shaping and line control, resulting in silkier, smoother lips and natural-looking results.
With full treatment, you can see lasting results for up to 18 months with Restylane;4* up to 12 months in the cheeks and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane Lyft;5 6 months with Restylane Silk;6 and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane Refyne and Restylane Defyne.1-3
Restylane Silk: In clinical studies, the results of Restylane Silk lasted approximately 6 months following treatment. In a U.S. clinical trial involving 221 mostly female subjects, 98% of subjects reported a visible improvement in lip fullness in upper and lower lip (combined) 14 days after injection, and 76% still had lip improvement at 6 months following injection.6
Restylane Lyft: In a clinical trial involving 200 subjects, investigators observed that 90% of subjects treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months.5
Restylane: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), at least 95% of subjects saw results for up to 18 months when they received an initial Restylane treatment, plus a follow-up treatment approximately 4.5 or 9 months later. Using this Restylane regimen of treatments, subjects showed similar improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.4
Restylane Refyne & Restylane Defyne: In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks.2,9,10
* The duration of effectiveness of Restylane for the correction of nasolabial folds (NLFs) was evaluated in a randomized, evaluator-blinded multicenter study. Restylane was shown to have an overall duration of effectiveness of 18 months from baseline following retreatment at 4.5 or 9 months.
Depending on your volume needs, most Restylane treatment appointments last less than an hour and begin to work almost immediately by adding volume to smooth away wrinkles. A clear gel formulation of hyaluronic acid, Restylane products act like your body's own hyaluronic acid (and eventually break down naturally). Each Restylane product is designed for a specific purpose.
There are several factors that figure into how much treatment will cost, including:
Since injection costs will vary from person to person, the best way to determine projected costs is to visit with your specialist.
Coupon or rebate programs through Galderma and/or a specialist may be available from time to time. It’s a good idea to ask your specialist if there’s a discount program available at the time of consultation. We highly recommend joining ASPIRE Galderma Rewards, our loyalty program that rewards you with special points, offers and rewards for every Galderma aesthetic treatment you receive — not just the Restylane family.
After your treatment, you may experience side effects, such as swelling, redness, pain, bruising, headache and itching at injection site and tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14-18 days in lips. Patients should be limited to 6.0 mL per treatment of moderate to severe facial wrinkles and folds. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Please see below for Important Safety Considerations for the Restylane family of products.
Initial Restylane treatments are usually complete in one or two sessions, as needed. Depending on your individual body chemistry, you will work with your specialist to determine a maintenance schedule. Talk to your physician or healthcare professional about your individual needs. Find a specialist near you.
You can only receive Restylane products from a trained specialist. Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne and Restylane Defyne are administered by a physician or qualified healthcare professional. Find a specialist near you.
The Restylane family of products should not be used by people who:
Rebates and treatment discounts are at the discretion of your local healthcare professional or med spa. However, we invite you to join our loyalty program — ASPIRE Galderma Rewards — to earn rewards, bonuses and discounts for any and all Galderma facial aesthetic treatments, including Restylane Silk, Restylane lyft, Restylane, Restylane Refyne and Restylane Defyne! Just be sure to ask your healthcare professional if his or her practice is part of the ASPIRE Galderma Rewards program.
The Restylane family of products includes Restylane®, Restylane-L®, Restylane® Lyft with Lidocaine, Restylane® Silk, Restylane® Refyne, and Restylane® Defyne. Restylane® and Restylane-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Restylane® and Restylane-L® are also indicated for injection into the lips in patients over the age of 21.