Treatment with a product from the Restylane^® family typically takes less than one hour. (Individual treatment times may vary.) Generally, there is minimal downtime associated with treatment using the Restylane family of products.

• Talk to your healthcare professional about options to make you as comfortable as possible during the procedure, including Restylane-L and pain medication.
• Your healthcare professional will cleanse and prepare the area(s) to be treated.
• The clear gel in the Restylane family of products is injected into the treatment area(s) using an ultra-fine needle to create the desired aesthetic effect.

With full treatment, you can see lasting results for up to 18 months with Restylane,^3* up to 12 months in the cheeks and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane Lyft;⁴ 6 months with Restylane Silk;⁵ and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane Refyne and Restylane Defyne.^1,2

Restylane Silk: In clinical studies, the results of Restylane Silk lasted approximately 6 months following treatment. In a U.S. clinical trial involving 221 mostly female subjects, 98% of subjects reported a visible improvement in lip fullness in upper and lower lip (combined) 14 days after injection, and 76% still had lip improvement at 6 months following injection.⁵

Restylane Lyft: In a clinical trial involving 200 subjects, investigators observed that 90% of subjects treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months.⁴

Restylane: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), blinded evaluators reported that 95% of subjects improved for up to 18 months when they received an initial Restylane treatment, plus a follow-up treatment approximately 4.5 or 9 months later. Using this Restylane regimen of treatments, blinded evaluators reported similar subject improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.⁶

Restylane Refyne & Restylane Defyne: In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks.^5,6,8,9

^*The duration of effectiveness of Restylane for the correction of nasolabial folds (NLFs) was evaluated in a randomized, evaluator-blinded multicenter study. Restylane was shown to have an overall duration of effectiveness of 18 months from baseline following retreatment at 4.5 or 9 months.

After your treatment, you may experience side effects, such as swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site and impaired hand function. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14-18 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Please see below for Important Safety Considerations for the Restylane family of products.

The Restylane family of products should not be used by people who:

• Are pregnant, breastfeeding, or under 22 years of age
• Have recently used drugs that thin the blood or prevent clotting
• Have had previous bad allergies, particularly to microorganisms known as gram-positive bacteria
• Have serious allergies to drugs that have previously required in-hospital treatment
• Have bleeding disorders
• Have a known allergy to lidocaine, if using  Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne or Restylane Defyne

Once you find a specialist in your area who administers Restylane^®, the following questions can help you get the most out of your appointment, and help you get the facts about treatment with Restylane products.

• Which of the products in the Restylane family is most appropriate for my treatment?
• What will you do to make me comfortable during my treatment?
• How long will the procedure last?
• What are the risks associated with treatment?
• What care is recommended after treatment?
• How much downtime will there be after I receive the treatment (time away from work, activities, etc.)?
• When should I schedule my follow-up appointment?

Before Treatment

• Avoid using aspirin, nonsteroidal anti-inflammatory medications (such as ibuprofen), St. John's wort or high doses of vitamin E supplements. These agents may increase bruising and bleeding at the injection site.
• Talk with your healthcare professional if you have previously suffered from facial cold sores. He or she may prescribe a medication to minimize recurrence.

After Treatment

After treatment, use this helpful checklist:

• Use cold compresses to reduce swelling.
• Avoid exposure to intense heat (sun lamp or sunbathing) or cold.
• Reduce the risk of facial cold sore recurrence that could be caused by needle punctures. Talk with your healthcare professional about medications that may minimize the likelihood of an outbreak.
• Avoid taking aspirin, nonsteroidal anti-inflammatory medications (such as ibuprofen), St. John's wort or high doses of vitamin E supplements for one week after treatment. These agents may increase bruising and bleeding at the injection site.
• If you’ve received a treatment in the back of your hands, avoid heavy or strenuous use of your hands immediately following treatment.
• After treatment, you might have some swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site and impaired hand function. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14–18 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years.
• Remember to ask about follow-up appointments.

Ready to get started with Restylane? Find a specialist in your area.