• The Restylane family
  • Where can Restylane be used?

Where can the Restylane® family of products be used?

The Restylane family can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, including the lines from your nose to the corners of your mouth (nasolabial folds or laugh lines).

The Restylane family can also be used in other moderate to severe facial wrinkles such as lipstick lines— the area just below the nose and above the upper lip; the corners of the mouth; and marionette lines—the area that extends downward from the corners of the mouth to the jawline.

Restylane and Restylane-L are the only FDA-approved dermal fillers for lip enhancement in patients over 21 years, and are uniquely formulated to give your lips fullness and definition. Learn more about Restylane for lip enhancement.

Lipstick Lines Marionette Lines Lips Corners of the Mouth Laugh Lines

Treatment volume should be limited to 6.0 mL in wrinkles and folds, such as nasolabial folds, and limited to 1.5 mL per lip (Restylane and Restylane-L only), as greater amounts significantly increase moderate and severe injection site reactions. The safety or effectiveness of treatment in areas other than nasolabial folds and lips (Restylane and Restylane-L only) has not been established in controlled clinical studies.

After treatment, you might have some swelling, redness, pain, bruising, or tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years.

Next: History and safety

*In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), Restylane continued to provide improvement for up to 18 months after initial treatment, when each line received a follow-up treatment at 4.5 or nine months.

The Restylane family of products includes Restylane, Restylane-L, Perlane, and Perlane-L. These products can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane and Restylane-L may also be used for lip enhancement in patients over 21 years. Ask your doctor which is right for you.

Important Safety Considerations for the Restylane family of products

Products in the Restylane family should not be used by people with previous bad allergies, particularly to microorganisms known as gram-positive bacteria, or by people with serious allergies to drugs that have previously required in-hospital treatment. These products should not be used by people with bleeding disorders. Products should not be injected anywhere except the skin, just under the skin (Perlane and Perlane-L only), or in the lips (Restylane and Restylane-L only). Restylane-L and Perlane-L should not be used by anyone with a known allergy to lidocaine.

Use at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. In these instances, product use could delay healing or make your skin problems worse. After treatment, you might have some swelling, redness, pain, bruising, or tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Rarely, the doctor may inject into a blood vessel, which can damage the skin. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause an outbreak. To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. Products should not be used during pregnancy, when breastfeeding, or in patients under 18 years for nasolabial folds.

Treatment volume should be limited to 6.0 mL in wrinkles and folds, such as nasolabial folds, and limited to 1.5 mL per lip (Restylane and Restylane-L only), as greater amounts significantly increase moderate and severe injection site reactions. The safety or effectiveness of treatment in areas other than nasolabial folds and lips (Restylane and Restylane-L only) has not been established in controlled clinical studies.

Medicis Aesthetics

The Restylane family of products is available only through a licensed practitioner.

The Restylane Family

For Moderate to Severe
Wrinkles & Folds

For Lip Enhancement in
Patients Over 21

Before & After Gallery

Resources & Rewards

Restylane, Restylane-L, Perlane, Perlane-L, and Restylane Rewards are registered trademarks of HA North American Sales AB. All other trademarks are the property of their respective owners. RES 12-032R2