History and safety

Restylane® injectable gel is the world's most studied wrinkle filler with more than a decade of use. Restylane has been used in more than 15 million treatments in more than 65 countries worldwide.* Products in the Restylane family have well-defined safety profiles and are approved for the treatment of moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).

Restylane and Restylane-L are the only FDA-approved dermal fillers for lip enhancement in patients over 21 years.

The Restylane family of products is made of a clear gel formulation of hyaluronic acid. Biocompatible with the human body, these products are eventually broken down naturally.

After your treatment, you might have some swelling, redness, pain, bruising, or tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years.

The Restylane family of products should not be used by people with previous bad allergies, particularly to microorganisms known as gram-positive bacteria, or by people with serious allergies to drugs that have previously required in-hospital treatment. These products should not be used by people with bleeding disorders. Products should not be injected anywhere except the skin, just under the skin (Perlane and Perlane-L only), or in the lips (Restylane and Restylane-L only). Restylane-L and Perlane-L should not be used by anyone with a known allergy to lidocaine.

To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. Products should not be used during pregnancy, when breastfeeding, or in patients under 18 years for nasolabial folds and under 21 years for lips.

*Includes Q-Med AB HA products not available in the United States.