The Restylane® Family

Get to know the Restylane family of products

With the Restylane family of products, time is on your side

The Restylane family of products includes Restylane, Restylane-L®, Perlane®, and Perlane-L®. These products are made of a clear gel formulation of hyaluronic acid, which is biocompatible with the human body and eventually broken down naturally. They can be used individually to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).

Restylane and Restylane-L are the only products FDA approved for lip enhancement in patients over 21 years, and are uniquely formulated to give your lips fullness and definition.

A History of beautiful results

Restylane injectable gel is the world's most studied wrinkle filler with more than a decade of use. Restylane has been used in more than 15 million treatments in more than 65 countries worldwide.* Products in the Restylane family have well-defined safety profiles and are approved for the treatment of moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).

*Includes Q-Med AB HA products not available in the United States.

Who should not use Restylane and Perlane?

The Restylane family of products should not be used by people who:

  • are pregnant, breastfeeding, or under 18 years for nasolabial folds and under 21 years for lips (Restylane and Restylane-L only).
  • have recently used drugs that thin the blood or prevent clotting
  • have had previous bad allergies, particularly to microorganisms known as gram-positive bacteria
  • have serious allergies to drugs that have previously required in-hospital treatment
  • have bleeding disorders
  • have a known allergy to lidocaine, if using Restylane-L or Perlane-L

Please see below for Important Safety Considerations for the Restylane family of products.

Important Safety Considerations

The Restylane family of products includes Restylane®, Restylane-L®, Perlane®, and Perlane-L®. These products can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane and Restylane-L may also be used for lip enhancement in patients over 21 years. Ask your doctor which is right for you.

Important Safety Considerations for the Restylane family of products
Products in the Restylane family should not be used by people with previous bad allergies, particularly to microorganisms known as gram-positive bacteria, or by people with serious allergies to drugs that have previously required in-hospital treatment. These products should not be used by people with bleeding disorders. Products should not be injected anywhere except the skin, just under the skin (Perlane and Perlane-L only), or in the lips (Restylane and Restylane-L only). Restylane-L and Perlane-L should not be used by anyone with a known allergy to lidocaine.

Use at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. In these instances, product use could delay healing or make your skin problems worse. After treatment, you might have some swelling, redness, pain, bruising, or tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Rarely, the doctor may inject into a blood vessel, which can damage the skin. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause an outbreak. To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. Products should not be used during pregnancy, when breastfeeding, or in patients under 18 years for nasolabial folds.

Treatment volume should be limited to 6.0 mL in wrinkles and folds, such as nasolabial folds, and limited to 1.5 mL per lip (Restylane and Restylane‑L only), as greater amounts significantly increase moderate and severe injection site reactions. The safety or effectiveness of treatment in areas other than nasolabial folds and lips (Restylane and Restylane‑L only) has not been established in controlled clinical studies.

The Restylane family of products is available only through a licensed practitioner.

Restylane, Restylane-L, Perlane, and Perlane-L are registered trademarks of HA North American Sales AB.
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