Perlane® & Perlane-L®

For wrinkles that benefit from a deeper injection

How does Perlane work?

Just like Restylane®, Perlane is a clear gel formulation of hyaluronic acid that is specifically formulated to act like your body's own hyaluronic acid, adding volume and fullness to the skin.

The most commonly observed side effects are swelling, redness, pain, bruising, and tenderness at the injection site. These are typically mild in severity and resolve in less than 7 days in nasolabial folds.

What makes Perlane different from Restylane?

What makes Perlane different than Restylane is the average size of the particles and the depth of injection, which means it's a good choice for more severe facial wrinkles that benefit from a deeper injection into the skin.

In three clinical studies

63%, 71% and 75%

of patients maintained improvement for six months after just one Perlane treatment

Perlane-L: A more comfortable wrinkle treatment experience*

If you want a more youthful appearance, but you’re concerned about the potential discomfort from treatment, you can get beautiful results and a more comfortable Perlane experience. By combining lidocaine with Perlane, Perlane-L helps reduce discomfort during and after treatment.

In clinical studies evaluating the Restylane family of products in laugh lines (nasolabial folds):

  • 95% of patients reported significantly less pain during treatment with Perlane-L vs. Perlane
  • Patients continued to experience less discomfort for up to one hour after treatment

Perlane and Perlane-L are not approved for use in lip enhancement. Perlane-L should not be used by anyone with a known allergy to lidocaine.

*When compared to Perlane

Choosing between Restylane and Perlane

Wondering if Restylane or Perlane is right for you? During your consultation, your healthcare professional will be able to help you make the right choice for treatment.

Products in the Restylane family should not be used by people with previous bad allergies, particularly to microorganisms known as gram-positive bacteria, or by people with serious allergies to drugs that have previously required in-hospital treatment. These products should not be used by people with bleeding disorders. Please see below for Important Safety Considerations for the Restylane family of products.

Important Safety Considerations

The Restylane family of products includes Restylane®, Restylane-L®, Perlane®, and Perlane-L®. These products can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane and Restylane-L may also be used for lip enhancement in patients over 21 years. Ask your doctor which is right for you.

Important Safety Considerations for the Restylane family of products
Products in the Restylane family should not be used by people with previous bad allergies, particularly to microorganisms known as gram-positive bacteria, or by people with serious allergies to drugs that have previously required in-hospital treatment. These products should not be used by people with bleeding disorders. Products should not be injected anywhere except the skin, just under the skin (Perlane and Perlane-L only), or in the lips (Restylane and Restylane-L only). Restylane-L and Perlane-L should not be used by anyone with a known allergy to lidocaine.

Use at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. In these instances, product use could delay healing or make your skin problems worse. After treatment, you might have some swelling, redness, pain, bruising, or tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Rarely, the doctor may inject into a blood vessel, which can damage the skin. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause an outbreak. To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. Products should not be used during pregnancy, when breastfeeding, or in patients under 18 years for nasolabial folds.

Treatment volume should be limited to 6.0 mL in wrinkles and folds, such as nasolabial folds, and limited to 1.5 mL per lip (Restylane and Restylane‑L only), as greater amounts significantly increase moderate and severe injection site reactions. The safety or effectiveness of treatment in areas other than nasolabial folds and lips (Restylane and Restylane‑L only) has not been established in controlled clinical studies.

The Restylane family of products is available only through a licensed practitioner.

Restylane, Restylane-L, Perlane, and Perlane-L are registered trademarks of HA North American Sales AB.
RES 12-128A

Medicis