Restylane^® and Perlane^® are cosmetic dermal fillers that replace lost volume and restore youthful contours to smooth away moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).

Restylane and Perlane have well defined safety profiles. Restylane has been used in over 1.4 million treatments in the U.S. and is available in more than 70 countries. It is the most studied dermal filler in the world with dozens of publications in the medical literature. Clinical studies have shown no significant differences in the safety of Restylane and Perlane.

Restylane and Perlane are made of hyaluronic acid. In the human body, natural hyaluronic acid provides volume and fullness to the skin. The hydrophilic or "water loving" nature of the hyaluronic molecules in Restylane and Perlane and their three dimensional structure allows them to bind many times their own weight in water. As hyaluronic acid begins to degrade, each molecule binds to more water which helps maintain its volume for about six months.

Important Safety Considerations of Restylane^®

For complete Restylane^® product and safety information, click here.

After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising or bleeding, you should not use Restylane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18, you should not use Restylane.

Restylane^® should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, by people with previous bad allergies to drugs that have required in-hospital treatment, or by people with bleeding disorders. Restylane should not be injected anywhere except the skin or just under the skin.

The use of Restylane^® at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of Restylane in these instances could delay healing or make your skin problems worse.

Important Safety Considerations of Perlane^®

For complete Perlane^® product and safety information, click here.

After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising or bleeding, you should not use Perlane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18, you should not use Perlane.

Perlane^® should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, by people with previous bad allergies to drugs that have required in-hospital treatment, or by people with bleeding disorders. Perlane should not be injected anywhere except the skin or just under the skin.

The use of Perlane^® at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of Perlane in these instances could delay healing or make your skin problems worse.

Learn more about skin and the aging process.