Restylane® has been used in over 1.4 million treatments in the U.S. and is available in 70 countries. It is the most studied cosmetic dermal filler in the world with dozens of publications in the medical literature. Clinical studies have shown no significant difference in the safety of Restylane and Perlane®. Studies have shown that Restylane generally lasts for about six months and Perlane lasts for at least six months in a majority of patients.*
Restylane and Perlane are formulated with a patented stabilization technology that helps maintain their cosmetic effect for those time periods.
Restylane® and Perlane® also offer other advantages:
- Contain no animal proteins
- Adverse events are generally mild to moderate
- No allergy testing required (Restylane and Perlane contain trace amounts of gram-positive bacterial proteins and are contraindicated for patients with a history of allergies to such material.)
*In 2 clinical studies, the number of patients maintaining ≥ one unit improvement at six months was 63% and 71% respectively.
Important Safety Considerations of Restylane®
For complete Restylane® product and safety information, click here.
Restylane® restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising or bleeding, you should not use Restylane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18, you should not use Restylane.
Restylane® should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, by people with previous bad allergies to drugs that have required in-hospital treatment, or by people with bleeding disorders. Restylane should not be injected anywhere except the skin or just under the skin.
The use of Restylane® at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of Restylane in these instances could delay healing or make your skin problems worse.
Important Safety Considerations of Perlane®
For complete Perlane® product and safety information, click here.
Perlane® restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising or bleeding, you should not use Perlane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18, you should not use Perlane.
Perlane® should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, by people with previous bad allergies to drugs that have required in-hospital treatment, or by people with bleeding disorders. Perlane should not be injected anywhere except the skin or just under the skin.
The use of Perlane® at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of Perlane in these instances could delay healing or make your skin problems worse.
View efficacy data for Restylane® and Perlane®.
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