Restylane^® and Perlane^® are proven to deliver long-lasting results: Studies have shown that Restylane generally lasts for about six months and Perlane lasts at least six months in a majority of patients.*

A randomized, evaluator-blinded, multi-center study compared the safety and efficacy of Restylane and Zyplast^® for the correction of nasolabial folds.

The following chart presents the percentage of patients (n=138, itt=137) who achieved or maintained at least one grade improvement on the Wrinkle Severity Rating Scale (WSRS) at different time points.




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*In 2 clinical studies, the number of patients maintaining ≥ one unit improvement at six months was 63% and 71% respectively.

Important Safety Considerations of Restylane^®

For complete Restylane^® product and safety information, click here.

Restylane^® restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising or bleeding, you should not use Restylane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18, you should not use Restylane.

Restylane^® should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, by people with previous bad allergies to drugs that have required in-hospital treatment, or by people with bleeding disorders. Restylane should not be injected anywhere except the skin or just under the skin.

The use of Restylane^® at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of Restylane in these instances could delay healing or make your skin problems worse.


Perlane^® was studied in two clinical studies. In one, treatment of the nasolabial folds with Perlane resulted in an improvement in wrinkles in 137 of 149 patients after three months, and 104 of 147 patients after six months. In the other study, treatment of nasolabial folds with Perlane resulted in an improvement in wrinkles in 122 of 141 patients after three months, and 87 of 138 patients after six months. Improvement was based on achieving or maintaining at least one grade improvement on the Wrinkle Severity Rating Scale (WSRS) over baseline. Side effects were generally mild to moderate. Most of the side effects went away in seven days. Post-exposure histopathology demonstrated that no patient developed cell-mediated immunity to Perlane.